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Furthermore, the FDA expedited the approval of nivolumab and pembrolizumab and nivolumab plus ipilimumab (a CTLA-4 inhibitor) for patients with advanced HCC who had previously been exposed to sorafenib

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Therefore, more than sufficient energy is available to produce 3 ATP from 3 ADP and 3 Pi (3 × 7.3 = 21.9 kcal/mol), sometimes expressed as a P:O ratio (ATP made per O atom reduced) of 3:1